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My Cart> Antibodies > Primary Antibodies > Anti-PD-L1/CD274 Polyclonal AntibodySAlexa Fluor 680Reactivity：Rat,Mouse,Human
Application：SAlexa Fluor 680
Clone Type：Polyclonal Antibody
Storage：Store at -20℃. Avoid freeze / thaw cycles.
Gene ID：29126
Host：Rabbit
Qty：
Size：
| Reactivity | Rat,Mouse,Human |
| Background | Programmed cell death ligand 1 (PD-L1, CD274, or B7-H1), is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors, the B7s are key regulators of the adaptive immune response. PD-L1 is suggested as a negative regulator of T and B cell, and plays important role in mediating tolerance of lymphocytes to self-antigens. It is also involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PD-1-independent manner. PD-L1 is a 290 aa transmembrane protein with a calculated molecular weight of 33 kDa, it is predicted to be 27-30 kDa after signal peptide cleavage (PMID: 25609200; 17076679). The apparent molecular weight has also been reported as 45-70 kDa, major glycosylated form of 45-50 kDa and multiple post-translational modifications form of 65-70 kDa (PMID: 18760278; 16493058). |
| Subtype | IgG |
| Storage | Store at -20℃. Avoid freeze / thaw cycles. |
| Host | Rabbit |
| Application | ELISA FCM IP IF IHC WB |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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