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My Cart> Antibodies > Primary Antibodies > Anti-VPS35 Polyclonal AntibodySAlexa Fluor 555Reactivity：Human,Rat,Mouse
Application：SAlexa Fluor 555
Clone Type：Polyclonal Antibody
Storage：Store at -20℃. Avoid freeze/thaw cycles.
Gene ID：55737
Host：Rabbit
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| Reactivity | Human,Rat,Mouse |
| Background | Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of low affinity and retromer SNX proteins may also contribute to cargo selectivity thus questioning the classical function of the CSC. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma m |
| Subtype | IgG |
| Storage | Store at -20℃. Avoid freeze/thaw cycles. |
| Host | Rabbit |
| Application | IHC |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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