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My Cart> Antibodies > Primary Antibodies > Anti-PILRA Polyclonal AntibodySAlexa Fluor 640Reactivity：Human,Mouse
Application：SAlexa Fluor 640
Clone Type：Polyclonal Antibody
Storage：Store at -20℃. Avoid freeze/thaw cycles.
Gene ID：29992
Host：Rabbit
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| Reactivity | Human,Mouse |
| Background | Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing，activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair，which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants，each encoding a distinct isoform，are described. |
| Subtype | IgG |
| Storage | Store at -20℃. Avoid freeze/thaw cycles. |
| Host | Rabbit |
| Application | WB IHC |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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