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My Cart> Antibodies > Primary Antibodies > Anti-SETX Polyclonal AntibodySAlexa Fluor 647Reactivity：Human,Mouse
Application：SAlexa Fluor 647
Clone Type：Polyclonal Antibody
Appearance：液体
Storage：Store at -20℃. Avoid freeze / thaw cycles.
Gene ID：23064
Host：Rabbit
Qty：
Size：
| Reactivity | Human,Mouse |
| Background | Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224).Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850).Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224, PubMed:26700805).Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation (By similarity).Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789).In association with RRP45, targets t |
| Subtype | IgG |
| Storage | Store at -20℃. Avoid freeze / thaw cycles. |
| Host | Rabbit |
| Application | IHC |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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