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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > CHIR-99021CAS：252917-06-9
Molecular Formula：C22H18Cl2N8
Molecular Weight：465.34
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to yellow Solid
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| CAS | 252917-06-9 |
| Name | CHIR-99021 |
| Molecular Formula | C22H18Cl2N8 |
| Molecular Weight | 465.34 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | HPLC≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 809-015-4 |
| MDL | MFCD11846251 |
| SMILES | N#CC1=CC=C(N=C1)NCCNC2=NC=C(C(C3=CC=C(Cl)C=C3Cl)=N2)C4=NC=C(N4)C |
| InChIKey | AQGNHMOJWBZFQQ-UHFFFAOYSA-N |
| InChI | InChI=1S/C22H18Cl2N8/c1-13-10-29-21(31-13)17-12-30-22(32-20(17)16-4-3-15(23)8-18(16)24)27-7-6-26-19-5-2-14(9-25)11-28-19/h2-5,8,10-12H,6-7H2,1H3,(H,26,28)(H,29,31)(H,27,30,32) |
| PubChem CID | 9956119 |
| Target Point | GSK-3;Wnt/β-catenin |
| Passage | PI3K/Akt/mTOR;Stem Cells |
| Background | It is a potent and selective GSK-3α/β inhibitor and a potent Wnt/β-catenin signaling pathway activator. |
| Biological Activity | CHIR-99021是 GSK-3α/β 抑制剂， IC50 分别为 10 nM，6.7 nM。 抑制 GSK-3α/β 比同源物 CDC2 和 ERK2 高 500 倍[1-4]。 |
| IC50 | GSK-3β:6.7nM;GSK-3α:10nM [1-4] |
| Data Literature Source | [1]. Ring DB，et al. Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes. 2003 Mar;52(3):588-95. [2]. Bennett CN，et al. Regulation of Wnt signaling during adipogenesis. J Biol Chem. 2002 Aug 23;277(34):30998-1004. [3]. Naujok O，et al. Cytotoxicity and activation of the Wnt/beta-catenin pathway in mouse embryonic stem cells treated with four GSK3 inhibitors.BMC Res Notes. 2014 Apr 29;7:273. [4]. Wang X，et al. Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation. Sci Rep. 2015 Apr 10;5:8566. |
| Unit | Piece |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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