{{cart_num}}
My CartReactivity：Mouse,Human
Application：IHC,WB,ELISA
Clone Type：Polyclonal Antibody
Storage：Store at -20℃. Avoid freeze / thaw cycles.
Gene ID：5243
Host：Rabbit
Qty：
Size：
| Name | Anti-ABCB1 Polyclonal Antibody |
| Host | Rabbit |
| Clone Type | Polyclonal Antibody |
| Subtype | IgG |
| Dilution Ratio | WB 1:1000-3000. IHC 1:50-200. |
| Target | ABCB1 |
| Background | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. |
| Swiss Prot | P08183 |
| Gene ID | 5243 |
| Subcellular Location | Cell membrane Cytoplasm |
| Immunogen | A synthetic peptide of Human ABCB1 |
| Public Immunogen Range | 660-710/1280aa |
| Calculated MW | 134/141kDa |
| Observed MW | 141kDa |
| Purification Method | Affinity purification |
| Storage Buffer | PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3. |
| Storage | Store at -20℃. Avoid freeze / thaw cycles. |
| Unit | Piece |
| Y-Dilution Ratio | WB 1:1000-3000. IHC 1:50-200. ELISA 1:10000-100000. |
| Specification | 20ul 50ul 100ul |
| Reactivity | Mouse Human |
| Application | IHC WB ELISA |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Kindly reminder：Quick spin before use. If you have any questions, please contact us.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Western blot analysis with ABCB1 antibody diluted at 1:2000;Lane: Mouse liver.
Immunohistochemistry of paraffin-embedded Human colorectal cancer with ABCB1 antibody diluted at 1:100.
Immunohistochemistry of paraffin-embedded Human pancreatic cancer with ABCB1 antibody diluted at 1:100.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
