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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > RamatrobanCAS：116649-85-5
Molecular Formula：C21H21FN2O4S
Molecular Weight：416.47
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 116649-85-5 |
| Name | Ramatroban |
| Molecular Formula | C21H21FN2O4S |
| Molecular Weight | 416.47 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00887606 |
| SMILES | O=C(O)CCN1C2=C(C3=C1C=CC=C3)C[C@H](NS(=O)(C4=CC=C(F)C=C4)=O)CC2 |
| InChIKey | LDXDSHIEDAPSSA-OAHLLOKOSA-N |
| InChI | InChI=1S/C21H21FN2O4S/c22-14-5-8-16(9-6-14)29(27,28)23-15-7-10-20-18(13-15)17-3-1-2-4-19(17)24(20)12-11-21(25)26/h1-6,8-9,15,23H,7,10-13H2,(H,25,26)/t15-/m1/s1 |
| PubChem CID | 123879 |
| Target Point | thromboxaneA2 synthetase |
| Passage | Metabolic Enzyme&Protease |
| Background | Ramatroban is a selective thromboxane A2 (TxA2) antagonist. |
| Biological Activity | Ramatroban is a selective thromboxane A2 (TxA2， IC50=14 nM) antagonist， which also antagonizes CRTH2 (IC50=113 nM) by inhibiting PGD2 binding.[1-3] |
| Data Literature Source | [1]. Stearns BA， et al. Novel tricyclic antagonists of the prostaglandin D2 receptor DP2 with efficacy in a murine modelof allergic rhinitis. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4647-51. [2]. Sugimoto H， et al. An orally bioavailable small molecule antagonist of CRTH2， ramatroban (BAY u3405)， inhibits prostaglandin D2-induced eosinophil migration in vitro. J Pharmacol Exp Ther. 2003 Apr;305(1):347-52. [3]. Haba R， et al. Central CRTH2， a second prostaglandin D2 receptor， mediates emotional impairment in the lipopolysaccharide and tumor-induced sickness behavior model. J Neurosci. 2014 Feb 12;34(7):2514-23. |
| Unit | Bottle |
| Specification | 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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