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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Others > PD 90780CAS：77422-99-2
Molecular Formula：C19H14N4O4
Molecular Weight：362.34
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 77422-99-2 |
| Name | PD 90780 |
| Molecular Formula | C19H14N4O4 |
| Molecular Weight | 362.34 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | CN1C2=CC(C(O)=O)=NN2C(C3=CC(NC(C4=CC=CC=C4)=O)=CC=C13)=O |
| InChIKey | IAZAGXDMMVWYKF-UHFFFAOYSA-N |
| InChI | InChI=1S/C19H14N4O4/c1-22-15-8-7-12(20-17(24)11-5-3-2-4-6-11)9-13(15)18(25)23-16(22)10-14(21-23)19(26)27/h2-10H,1H3,(H,20,24)(H,26,27) |
| PubChem CID | 9885305 |
| Target Point | NGF |
| Passage | Others |
| Background | PD 90780 is a non-peptide NGF antagonist that binds to the p75 receptor on NGF and inhibits the interaction of NGF with neurotrophin receptor p75 NTR (NGF-p75 NTR). |
| Biological Activity | PD 90780 is a non peptide antagonist of nerve growth factor (NGF). PD 90780 interacts with NGF， prevents NGF binds with p75NTR. PD 90780 inhibits NGF-p75NTR interaction with IC50s of 23.1 and 1.8 μM in PC12 cells and PC12nnr5 cells， respectively[1] . |
| IC50 | IC50: 23.1 μM (NGF-p75NTR， PC12 cells)， 1.8 μM (NGF-p75NTR， PC12nnr5 cells)[1] |
| Data Literature Source | [1]. Colquhoun A ，et al. Differential activity of the nerve growth factor (NGF) antagonist PD90780 [7-(benzolylamino)-4，9-dihydro-4-methyl-9-oxo-pyrazolo[5，1-b]quinazoline-2-carboxylic acid] suggests altered NGF-p75NTR interactions in the presence of TrkA. J |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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