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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > AX-024 HydrochlorideCAS：1704801-24-0
Molecular Formula：C21H23ClFNO2
Molecular Weight：375.86
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1704801-24-0 |
| Name | AX-024 Hydrochloride |
| Molecular Formula | C21H23ClFNO2 |
| Molecular Weight | 375.86 |
| Solubility | Soluble in Water/DMSO ≥1mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD31628548 |
| SMILES | COC1=CC=C(OC2)C(C(C3=CC=C(F)C=C3)=C2CN4CCCC4)=C1.[H]Cl |
| InChIKey | DGBCIMPGYRVTPD-UHFFFAOYSA-N |
| InChI | InChI=1S/C21H22FNO2.ClH/c1-24-18-8-9-20-19(12-18)21(15-4-6-17(22)7-5-15)16(14-25-20)13-23-10-2-3-11-23;/h4-9,12H,2-3,10-11,13-14H2,1H3;1H |
| PubChem CID | 129909862 |
| Target Point | TCR;IFNAR；Interleukin Related |
| Passage | Immunology & Inflammation |
| Background | It is a TCR-Nck interaction inhibitor, which can selectively inhibit TCR-triggered T cell activation. It also effectively inhibits the production of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), IL-10 and IL-17A. |
| Biological Activity | AX-024 hydrochloride is an orally available， first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC50 ~1 nM. AX-024 hydrochloride modulates cell signaling by targeting SH3 domains. AX-024 hydrochloride has low-acute toxicity and high potency and selectivity， and strongly inhibit the production of IL-6， TNF-α， IFN-γ， IL-10 and IL-17A.[1] |
| Data Literature Source | [1]. Borroto A， et al. First-in-class inhibitor of the T cell receptor for the treatment of autoimmune diseases. Sci Transl Med. 2016 Dec 21;8(370):370ra184. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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