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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > CopanlisibCAS：1032568-63-0
Molecular Formula：C23H28N8O4
Molecular Weight：480.52
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Off-white to brown Solid
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| CAS | 1032568-63-0 |
| Name | Copanlisib |
| Molecular Formula | C23H28N8O4 |
| Molecular Weight | 480.52 |
| Solubility | Soluble in Water ≥1mg/mL(Need to add HCl dropwise to help dissolve) |
| Purity | ≥98% |
| Appearance | Off-white to brown Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD18633201 |
| SMILES | O=C(C1=CN=C(N)N=C1)NC2=NC3=C(OC)C(OCCCN4CCOCC4)=CC=C3C5=NCCN25 |
| InChIKey | MWYDSXOGIBMAET-UHFFFAOYSA-N |
| InChI | InChI=1S/C23H28N8O4/c1-33-19-17(35-10-2-6-30-8-11-34-12-9-30)4-3-16-18(19)28-23(31-7-5-25-20(16)31)29-21(32)15-13-26-22(24)27-14-15/h3-4,13-14,25H,2,5-12H2,1H3,(H2,24,26,27) |
| PubChem CID | 135565596 |
| Target Point | PI3K |
| Passage | PI3K/Akt/mTOR |
| Background | It is an ATP-competitive, selective type I PI3K inhibitor. |
| Biological Activity | Copanlisib (BAY 80-6946) is a potent， selective and ATP-competitive pan-class I PI3K inhibitor， with IC50s of 0.5 nM， 0.7 nM， 3.7 nM and 6.4 nM for PI3Kα， PI3Kδ， PI3Kβ and PI3Kγ， respectively. Copanlisib has more than 2，000-fold selectivity against other lipid and protein kinases， except for mTOR. Copanlisib has superior antitumor activity[1]. |
| Data Literature Source | [1]. Liu N，et al. BAY 80-6946 is a highly selective intravenous PI3K inhibitor with potent p110α and p110δ activities in tumor cell lines and xenograft models. Mol Cancer Ther. 2013 Nov;12(11):2319-30. |
| Unit | Bottle |
| Specification | 2mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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