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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Others > 25-HydroxycholesterolCAS：2140-46-7
Molecular Formula：C27H46O2
Molecular Weight：402.65
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 2140-46-7 |
| Name | 25-Hydroxycholesterol |
| Molecular Formula | C27H46O2 |
| Molecular Weight | 402.65 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00057815 |
| SMILES | CC(C)(O)CCC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C |
| InChIKey | CC(C)(O)CCC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C |
| InChI | InChI=1S/C27H46O2/c1-18(7-6-14-25(2，3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19，4)24(21)13-16-27(22，23)5/h8，18，20-24，28-29H，6-7，9-17H2，1-5H3/t18-，20+，21+，22-，23+，24+，26+，27-/m1/s1 |
| PubChem CID | 65094 |
| Target Point | Others |
| Passage | Others |
| Background | It is reported that 25-Hydroxycholesterol effectively and selectively inhibits the production of IgA by B cells. |
| Biological Activity | 25-Hydroxycholesterol is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells.[1] |
| Data Literature Source | [1]. McDonald JG，et al. Editorial: 25-Hydroxycholesterol: a new life in immunology. J Leukoc Biol. 2010 Dec;88(6):1071-2. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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