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My Cart> Peptides > Neuropeptides & Related Peptides > Neurogranin 28-43 [AAKIQASFRGHMARKK], BiotinylatedMolecular Formula：C88H148N30O21S2
Molecular Weight：2026.46
Purity：≥95%
Appearance：Lyophilized powder
Storage：Store at -20℃，2 years.(Avoid freeze/thaw cycles)
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| Product Type | Peptides |
| Sequence(1LC) | Biotin-AAKIQASFRGHMARKK |
| Sequence(3LC) | Biotin-Ala-Ala-Lys-Ile-Gln-Ala-Ser-Phe-Arg-Gly-His-Met-Ala-Arg-Lys-Lys |
| Molecular Formula | C88H148N30O21S2 |
| Molecular Weight | 2026.46 |
| Purity | ≥95% |
| Appearance | Lyophilized powder |
| Salt Form | Trifluoroacetate salt |
| Source | Synthetic |
| Storage | Store at -20℃，2 years.(Avoid freeze/thaw cycles) |
| Category/Label | Neuropeptides and Related Peptides |
| Background | The native peptide AAKIQASFRGHMARKK is a synthetic PKC substrate derived from the sequence of neurogranin, a naturally occurring PKC substrate. The peptide is proven to be a PKC substrate with quite good specificity. It is phosphorylated by purified PKC with a Km of 150 nM. No significant phosphorylation of the peptide by either PKA or by CaMK 2 is reported. Substituting Arg36 with Ile causes a significant reduction in the affinity for PKC. Replacing Lys30 with Arg enhances the catalytic efficiency (Vmax/Km) for PKC but diminishes the selectivity of the substrate for PKC. It is generally considered that basic amino acids on both sides of the phosphorylated Ser are important structural determinants in PKC substrates. In addition, the presence of particular basic amino acids (Arg vs Lys) may also contribute to the degree of selectivity of a substrate for PKC. |
| Reference | [1] Chang, DK. et al. Biophys. J. 72, 554 (1997); [2] Chen, SJ. et al. Biochem. 32, 1032 (1993). |
| Unit | Bottle |
| Specification | 1mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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