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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > CNX-2006CAS：1375465-09-0
Molecular Formula：C26H27F4N7O2
Molecular Weight：545.53
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1375465-09-0 |
| Name | CNX-2006 |
| Molecular Formula | C26H27F4N7O2 |
| Molecular Weight | 545.53 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | C=CC(NC1=CC=CC(NC2=NC(NC3=CC=C(NC4CN(CCF)C4)C=C3OC)=NC=C2C(F)(F)F)=C1)=O |
| Target Point | EGFR |
| Passage | Angiogenesis;Protein Tyrosine Kinase/RTK; JAK/STAT Signaling |
| Background | CNX-2006 is an irreversible EGFR mutant inhibitor. |
| Data Literature Source | [1] Ohashi K，et al. Abstract 2101A: CNX-2006，a novel irreversible epidermal growth factor receptor (EGFR) inhibitor，selectively inhibits EGFR T790M and fails to induce T790M-mediated resistance in vitro.[J]. Cancer Research，2013，73(8 Supplement):2101A-2101A. [2] Galvani E，et al. Abstract 3244: Role of epithelial-mesenchymal transition (EMT) in sensitivity to CNX-2006，a novel mutant-selective EGFR inhibitor which overcomes in vitro T790M-mediated resistance in NSCLC.[J]. Cancer Research，2013，73(8 Supplement):3244-3244. |
| Unit | Bottle |
| Specification | 2mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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