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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > CapsazepineCAS：138977-28-3
Molecular Formula：C19H21ClN2O2S
Molecular Weight：376.9
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 138977-28-3 |
| Name | Capsazepine |
| Molecular Formula | C19H21ClN2O2S |
| Molecular Weight | 376.9 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00153778 |
| SMILES | S=C(N1CCCC2=CC(O)=C(O)C=C2C1)NCCC3=CC=C(Cl)C=C3 |
| Target Point | TRPV1 |
| Passage | Membrane Transporter&Ion Channel;Neuronal Signaling |
| Background | Capsazepine is a TRPV1 receptor antagonist. |
| Biological Activity | Capsazepine是TRPV1的拮抗剂，IC50 为562 nM。[1-4] |
| IC50 | TRPV1：562nM[1] |
| Data Literature Source | [1]. Sung B，et al. Capsazepine，a TRPV1 antagonist，sensitizes colorectal cancer cells to apoptosis by TRAIL through ROS-JNK-CHOP-mediated upregulation of death receptors. Free Radic Biol Med. 2012 Nov 15;53(10):1977-87. [2]. Santicioli P，et al. Effect of capsazepine on the release of calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) induced by low pH，capsaicin and potassium in rat soleus muscle. Br J Pharmacol. 1993 Oct;110(2):609-12. [3]. Cabral LD，et al. The Transient Receptor Potential Vanilloid 1 Antagonist Capsazepine Improves the Impaired Lung Mechanics during Endotoxemia. Basic Clin Pharmacol Toxicol. 2016 Nov;119(5):421-427. [4]. Wang J，et al. Anti-inflammatory and retinal protective effects of capsaicin on ischaemia-induced injuries through the release of endogenous somatostatin. Clin Exp Pharmacol Physiol. 2017 Jul;44(7):803-814. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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