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CB-839

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Cat.No：IC2470 Solarbio

CAS：1439399-58-2

Molecular Formula：C₂₆H₂₄F₃N₇O₃S

Molecular Weight：571.57

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Off-white to yellow Solid

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Product Information

CAS	1439399-58-2
Name	CB-839
Molecular Formula	C₂₆H₂₄F₃N₇O₃S
Molecular Weight	571.57
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Off-white to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD28167826
SMILES	O=C(NC1=NN=C(CCCCC2=NN=C(NC(CC3=CC=CC(OC(F)(F)F)=C3)=O)C=C2)S1)CC4=NC=CC=C4
Target Point	Glutaminase
Passage	Metabolic Enzyme&Protease
Background	CB-839 is a potent and selective glutaminase inhibitor.
Biological Activity	CB-839 (Telaglenastat) 是一种有效的，选择性的，口服生物可利用的 glutaminase 抑制剂，对重组人GAC的 IC50 为 24 nM。CB-839(Telaglenastat)可诱导自噬并具有抗肿瘤活性。[1]
Data Literature Source	[1]. Gross MI，Demo SD，Dennison JB，Chen L，Chernov-Rogan T，Goyal B，Janes JR，Laidig GJ，Lewis ER，Li J，Mackinnon AL，Parlati F，Rodriguez ML，Shwonek PJ，Sjogren EB，Stanton TF，Wang T，Yang J，Zhao F，Bennett MK. Antitumor activity of the glutaminase inhibitor CB-839 in triple-negative breast cancer. Mol Cancer Ther. 2014 Apr;13(4):890-901.
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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