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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Protein Tyrosine Kinase/PTK > CeritinibCAS：1032900-25-6
Molecular Formula：C28H36ClN5O3S
Molecular Weight：558.14
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1032900-25-6 |
| Name | Ceritinib |
| Molecular Formula | C28H36ClN5O3S |
| Molecular Weight | 558.14 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 811-457-8 |
| MDL | MFCD26142648 |
| SMILES | CC(C)OC1=CC(C2CCNCC2)=C(C)C=C1NC3=NC=C(Cl)C(NC4=CC=CC=C4S(=O)(C(C)C)=O)=N3 |
| Target Point | ALK |
| Passage | Protein Tyrosine Kinase/RTK;Angiogenesis |
| Background | Ceritinib is a potent ALK inhibitor. |
| Biological Activity | Ceritinib (LDK378) 是有效且特异性的 ALK 抑制剂，IC50 为 0.2 nM。[1-3] |
| IC50 | 0.2nM(ALK);7nM(InsR);8nM(IGF-1R);23nM(STK22D);60nM(FLT3);260nM(FGFR2)[1] |
| Data Literature Source | [1]. Marsilje TH，et al. Synthesis，structure-activity relationships，and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl [2]. Chen J，et al. LDK378: a promising anaplastic lymphoma kinase (ALK) inhibitor. J Med Chem. 2013 Jul 25;56(14):5673-4. [3]. Tucker ER，et al. Immunoassays for the quantification of ALK and phosphorylated ALK support the evaluation of on-target ALK inhibitors in neuroblastoma. Mol Oncol. 2017 Aug;11(8):996-1006. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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