{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > AR-A014418CAS：487021-52-3
Molecular Formula：C12H12N4O4S
Molecular Weight：308.31
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
Qty：
Size：
| CAS | 487021-52-3 |
| Name | AR-A014418 |
| Molecular Formula | C12H12N4O4S |
| Molecular Weight | 308.31 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00063278 |
| SMILES | COC1=CC=C(C=C1)CNC(=O)NC2=NC=C(S2)[N+](=O)[O-] |
| Target Point | GSK-3 |
| Passage | PI3K/Akt/mTOR;Stem Cells |
| Background | AR-A014418 is a potent, selective, and ATP-competitive inhibitor of GSK3β. |
| Biological Activity | AR-A014418 是一种有效，选择性，ATP 竞争性的 GSK3β 抑制剂，IC50 值为 104 nM。[1-4] |
| Data Literature Source | [1]. Bhat R，Xue Y，Berg S，Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418. J Biol Chem. 2003 Nov 14;278(46):45937-45. [2]. Carter YM，et al. Specific glycogen synthase kinase-3 inhibition reduces neuroendocrine markers and suppresses neuroblastoma cell growth. Cancer Biol Ther. 2014 May;15(5):510-5. [3]. Koh SH，et al. Inhibition of glycogen synthase kinase-3 suppresses the onset of symptoms and disease progression of G93A-SOD1 mouse model of ALS. Exp Neurol. 2007 Jun;205(2):336-46 [4]. Martins DF，et al. The antinociceptive effects of AR-A014418，a selective inhibitor of glycogen synthase kinase-3 beta，in mice. J Pain. 2011 Mar;12(3):315-22 |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
