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My CartCAS：17650-98-5
Molecular Formula：C58H73N13O21S2
Molecular Weight：1352.4
Storage：Powder:-20℃，1 year;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 17650-98-5 |
| Name | Caerulein |
| Molecular Formula | C58H73N13O21S2 |
| Molecular Weight | 1352.4 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，1 year;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 17650-98-5 |
| MDL | MFCD00076478 |
| SMILES | O=C(N[C@@H](CCSC)C(N[C@@H](CC(O)=O)C(N[C@H](C(N)=O)CC1=CC=CC=C1)=O)=O)[C@@H](NC(CNC([C@@]([C@H](O)C)([H])NC([C@@H](NC([C@H](CC(O)=O)NC([C@H](CCC(N)=O)NC([C@H](CC2)NC2=O)=O)=O)=O)CC3=CC=C(OS(=O)(O)=O)C=C3)=O)=O)=O)CC4=CNC5=C4C=CC=C5 |
| Target Point | Cholecystokinin Receptor |
| Passage | GPCR & G Protein |
| Background | It is a potent cholecystokinin receptor agonist. |
| Biological Activity | Ceruletide (Caerulein) 是从澳大利亚青蛙皮肤中分离的生物活性十肽，一种有效的胆囊收缩剂，为缩胆囊素受体 (cholecystokinin receptor) 激动剂。[1-4] |
| Data Literature Source | [1]. Vincent ME，et al. Pharmacology，clinical uses，and adverse effects of ceruletide，a cholecystokinetic agent. Pharmacotherapy. 1982 Jul-Aug;2(4):223-34. [2]. Steinle AU，et al. NF-kappaB/Rel activation in cerulein pancreatitis. Gastroenterology. 1999 Feb;116(2):420-30. [3]. Bridger N，et al. Comparison of postprandial and ceruletide serum bile acid stimulation in dogs. J Vet Intern Med. 2008 Jul-Aug;22(4):873-8. [4]. Zarrindast MR，et al. Effects of cholecystokinin receptor agonist and antagonists on morphine dependence in mice. Pharmacol Toxicol. 1995 Dec;77(6):360-4. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Wang XD, Yu WL, Sun Y. Life Sci. 2021 Jul 15;277:119435.
Wang XD, Yu WL, Sun Y. Life Sci. 2021 Jul 15;277:119435.
Xue B H, et al. Molecular and Cellular Biochemistry, 2020(136).
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