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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > AZD-1080CAS：612487-72-6
Molecular Formula：C19H18N4O2
Molecular Weight：334.37
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to orange Solid
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| CAS | 612487-72-6 |
| Name | AZD-1080 |
| Molecular Formula | C19H18N4O2 |
| Molecular Weight | 334.37 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to orange Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD12031593 |
| SMILES | OC(N1)=C(C2=CC=C(CN3CCOCC3)C=N2)C4=C1C=CC(C#N)=C4 |
| Target Point | GSK-3 |
| Passage | PI3K/Akt/mTOR;Stem Cells |
| Background | AZD-1080 is a potent and selective GSK3 inhibitor. |
| Biological Activity | AZD1080 是一种有效的选择性 GSK3 抑制剂。AZD1080 抑制重组人 GSK3α 和 GSK3β，pKi (IC50) 分别为 8.2 (6.9 nM) 和 7.5 (31 nM)。[1] |
| Data Literature Source | [1]. Georgievska B，et al. AZD1080，a novel GSK3 inhibitor，rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans. J Neurochem. 2013 May;125(3):446-56 |
| Unit | Bottle |
| Specification | 1mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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