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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > DNA Damage & DNA Repai > AZ-20CAS：1233339-22-4
Molecular Formula：C21H24N4O3S
Molecular Weight：412.51
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1233339-22-4 |
| Name | AZ-20 |
| Molecular Formula | C21H24N4O3S |
| Molecular Weight | 412.51 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD25976730 |
| SMILES | O=S(C1(C2=CC(N3[C@H](C)COCC3)=NC(C4=CC=CC5=C4C=CN5)=N2)CC1)(C)=O |
| Target Point | ATR，mTOR |
| Passage | DNA Damage/DNA Repair; PI3K/Akt/mTOR |
| Background | AZ-20 is a potent and selective ATR inhibitor; also inhibits mTOR activity. |
| Biological Activity | AZ20 是一种有效的，选择性的 ATR 抑制剂，IC50 值为 5 nM；同时可抑制 mTOR 活性，IC50 值为 38 nM。[1] |
| IC50 | ATR:5nM;mTOR:38nM;PI3Kα:13000nM [1] |
| Data Literature Source | [1]. Foote KM，et al. Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity. J Med Chem. 2013 Mar 14 |
| Unit | Bottle |
| Specification | 2mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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