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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > AnagliptinCAS：739366-20-2
Molecular Formula：C19H25N7O2
Molecular Weight：383.45
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Off-white to yellow Solid
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| CAS | 739366-20-2 |
| Name | Anagliptin |
| Molecular Formula | C19H25N7O2 |
| Molecular Weight | 383.45 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Off-white to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | O=C(C1=CN2C(N=C1)=CC(C)=N2)NCC(C)(NCC(N3[C@H](C#N)CCC3)=O)C |
| Target Point | DPP4 |
| Passage | Metabolic Enzyme&Protease |
| Background | Anagliptin is a highly selective and potent dipeptidyl peptidase 4 (DPP-4) inhibitor. |
| Biological Activity | Anagliptin (SK-0403) is a highly selective， potent， orally active inhibitor of dipeptidyl peptidase 4 (DPP-4)， with an IC50 of 3.8 nM， and less selective at DPP-8 and DDP-9 with IC50s of 68 nM and 60 nM， respectively[1]. |
| IC50 | DPP-4 3.8 nM (IC50).DPP-9 60 nM (IC50).DPP-8 68 nM (IC50) |
| Data Literature Source | [1]. Kato N，et al. Discovery and pharmacological characterization of N-[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)-2-methylpropyl]-2-methylpyrazolo[1，5-a]pyrimidine-6-carboxamide hydrochloride (anagliptin hydrochloride salt) as a potent and selective DPP-IV inhibitor. Bioorg Med Chem. 2011 Dec 1;19(23):7221-7. [2]. Ervinna N，et al. Anagliptin，a DPP-4 inhibitor，suppresses proliferation of vascular smooth muscles and monocyte inflammatory reaction and attenuates atherosclerosis in male apo E-deficient mice. Endocrinology. 2013 Mar;154(3):1260-70. [3]. Yano W，et al. Mechanism of lipid-lowering action of the dipeptidyl peptidase-4 inhibitor，anagliptin，in low-density lipoprotein receptor-deficient mice. J Diabetes Investig. 2017 Mar;8(2):155-160. |
| Unit | Bottle |
| Specification | 2mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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