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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Protein Tyrosine Kinase/PTK > AltiratinibCAS：1345847-93-9
Molecular Formula：C26H21F3N4O4
Molecular Weight：510.46
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to brown Solid
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| CAS | 1345847-93-9 |
| Name | Altiratinib |
| Molecular Formula | C26H21F3N4O4 |
| Molecular Weight | 510.46 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to brown Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD28900672 |
| SMILES | O=C(C1(C(NC2=CC=C(F)C=C2)=O)CC1)NC3=CC(F)=C(OC4=CC(NC(C5CC5)=O)=NC=C4)C=C3F |
| Target Point | TRK;c-Met;TIE2;VEGFR2 |
| Passage | Angiogenesis;Protein Tyrosine Kinase/RTK;Neuronal Signaling |
| Background | It is a multi-target kinase inhibitor that inhibits MET, TIE2, VEGFR2, FLT3, Trk1, Trk2 and Trk3, etc. |
| Biological Activity | Altiratinib (DCC-2701) inhibits not only mechanisms of tumor initiation and progression, but also drug resistance mechanisms in the tumor and microenvironment through balanced inhibition of MET, TIE2 (TEK), and VEGFR2 (KDR) kinases. Altiratinib durably inhibits MET, both wild-type and mutated forms, in vitro and in vivo. Through its balanced inhibitory potency versus MET, TIE2, and VEGFR2, altiratinib provides an agent that inhibits three major evasive (re)vascularization and resistance pathways (HGF, ANG, and VEGF) and blocks tumor invasion and metastasis. Altiratinib exhibits properties amenable to oral administration and exhibits substantial blood-brain barrier penetration, an attribute of significance for eventual treatment of brain cancers and brain metastases.[1] |
| Data Literature Source | 1] Smith BD，et al. Mol Cancer Ther. 2015，14(9):2023-34. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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