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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Stem Cells > Wnt-C59CAS：1243243-89-1
Molecular Formula：C25H21N3O
Molecular Weight：379.45
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Off-white to brown Solid
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| CAS | 1243243-89-1 |
| Name | Wnt-C59 |
| Molecular Formula | C25H21N3O |
| Molecular Weight | 379.45 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Off-white to brown Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD22201167 |
| SMILES | CC1=NC=CC(=C1)C2=CC=C(C=C2)CC(=O)NC3=CC=C(C=C3)C4=CN=CC=C4 |
| Target Point | PORCN |
| Passage | Stem Cells |
| Background | Wnt-C59 is a PORCN inhibitor. |
| Biological Activity | Wnt-C59 (C59)是高效可口服的 PORCN 抑制剂，IC50 为 74 pM。[1-2] |
| Data Literature Source | [1]. Proffitt KD，et al. Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer. Cancer Res. 2013 Jan 15;73(2):502-7. [2]. Cheng Y，et al. Wnt-C59 arrests stemness and suppresses growth of nasopharyngeal carcinoma in mice by inhibiting the Wnt pathway in the tumor microenvironment. Oncotarget. 2015 Jun 10;6(16):14428-39 |
| Unit | Bottle |
| Specification | 1mg 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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