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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > Thiamet GCAS：1009816-48-1
Molecular Formula：C9H16N2O4S
Molecular Weight：248.3
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to light yellow Solid
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| CAS | 1009816-48-1 |
| Name | Thiamet G |
| Molecular Formula | C9H16N2O4S |
| Molecular Weight | 248.3 |
| Solubility | Soluble in Water/DMSO ≥1mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to light yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD15144964 |
| SMILES | O[C@H]1[C@H](O)[C@@]2([H])N=C(NCC)S[C@@]2([H])O[C@@H]1CO |
| InChIKey | PPAIMZHKIXDJRN-FMDGEEDCSA-N |
| InChI | InChI=1S/C9H16N2O4S/c1-2-10-9-11-5-7(14)6(13)4(3-12)15-8(5)16-9/h4-8，12-14H，2-3H2，1H3，(H，10，11)/t4-，5-，6-，7-，8-/m1/s1 |
| PubChem CID | 135566354 |
| Target Point | O-GlcNAcase |
| Passage | Metabolic Enzyme&Protease |
| Background | Thiamet G is a potent and selective inhibitor of O-GlcNAcase. |
| Biological Activity | Thiamet G is a potent and selective inhibitor of O-GlcNAcase (OGA)， which acts to remove O-GlcNAc from modified proteins， with Ki of 20 nM for human OGA.[1-3] |
| IC50 | Ki: 20nM(Human OGA)[1] |
| Data Literature Source | [1]. Yuzwa SA，et al. Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation. Nat Chem Biol. 2012 Feb 26;8(4):393-9. [2]. Andrés-Bergós J，et al. The increase in O-linked N-acetylglucosamine protein modification stimulates chondrogenic differentiation both in vitro and in vivo. J Biol Chem. 2012 Sep 28;287(40):33615-28. [3]. Ding N，et al. Thiamet-G-mediated inhibition of O-GlcNAcase sensitizes human leukemia cells to microtubule-stabilizing agent NSC 125973. Biochem Biophys Res Commun. 2014 Oct 24;453(3):392-7. |
| Unit | Bottle |
| Specification | 5mg 10mg 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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