Your Position: Home > Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > BMS-687453

BMS-687453

Manual Download

Cat.No：IB2880 Solarbio

CAS：1000998-59-3

Molecular Formula：C₂₂H₂₁ClN₂O₆

Molecular Weight：444.9

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

Qty：

Size：

Add to cart

Product Information Experimental Images Related Products Related Paper Technical Q&A

Product Information

CAS	1000998-59-3
Name	BMS-687453
Molecular Formula	C₂₂H₂₁ClN₂O₆
Molecular Weight	444.9
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD18251482
SMILES	CC1=C(N=C(O1)C2=CC=C(C=C2)Cl)COC3=CC=CC(=C3)CN(CC(=O)O)C(=O)OC
Target Point	PPAR
Passage	Cell Cycle;DNA Damage/DNA Repair;Metabolic Enzyme&Protease
Background	BMS-687453 is a potent and selective PPARα agonist.
Biological Activity	BMS-687453 is a potent and selective PPARα agonist， with an EC50 and IC50 of 10 nM and 260 nM for human PPARα and 4100 nM and >15000 nM for PPARγ in PPAR-GAL4 transactivation assays.[1-3]
Data Literature Source	[1]. Li J，et al. Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453). J Med Chem. 2010 Apr 8;53 [2]. Mukherjee R，et al. Novel peroxisome proliferator-activated receptor alpha agonists lower low-density lipoprotein and triglycerides，raise high-density lipoprotein，and synergistically increase cholesterol excretion with a liver X receptor agonist. J Phar [3]. Vassallo JD，et al. Biomarkers of drug-induced skeletal muscle injury in the rat: troponin I and myoglobin. Toxicol Sci. 2009 Oct;111(2):402-12.
Unit	Bottle
Specification	5mg 10mg 25mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

Note：

1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.

2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.

3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.