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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > TM5275 SodiumCAS：1103926-82-4
Molecular Formula：C28H28ClN3NaO5
Molecular Weight：544.98
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1103926-82-4 |
| Name | TM5275 Sodium |
| Molecular Formula | C28H28ClN3NaO5 |
| Molecular Weight | 544.98 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD28396414 |
| SMILES | C1CN(CCN1C(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)COCC(=O)NC4=C(C=C(C=C4)Cl)C(=O)[O-].[Na+] |
| Target Point | PAI-1 |
| Passage | Metabolic Enzyme&Protease |
| Background | TM5275 Sodium is a plasminogen activator inhibitor (PAI-1). |
| Biological Activity | TM5275 sodium is a plasminogen activator inhibitor (PAI-1) with an IC50 of 6.95 μM.[1-3] |
| IC50 | IC50: 6.95 μM (PAI-1)[1] |
| Data Literature Source | [1]. Izuhara Y， et al. A novel inhibitor of plasminogen activator inhibitor-1 provides antithrombotic benefits devoid of bleeding effect in nonhuman primates. J Cereb Blood Flow Metab. 2010 May;30(5):904-12. [2]. Yasui H， et al. TM5275 prolongs secreted tissue plasminogen activator retention and enhances fibrinolysis on vascular endothelial cells. Thromb Res. 2013 Jul;132(1):100-5. [3]. Mashiko S， et al. Inhibition of plasminogen activator inhibitor-1 is a potential therapeutic strategy in ovarian cancer. Cancer Biol Ther. 2015;16(2):253-60. |
| Unit | Bottle |
| Specification | 1mg 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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