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A-769662

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Cat.No：IA2830 Solarbio

CAS：844499-71-4

Molecular Formula：C₂₀H₁₂N₂O₃S

Molecular Weight：360.39

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Light yellow to brown Solid

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Product Information

CAS	844499-71-4
Name	A-769662
Molecular Formula	C₂₀H₁₂N₂O₃S
Molecular Weight	360.39
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Light yellow to brown Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD11977269
SMILES	N#CC1C(C2=C(NC1=O)SC=C2C3=CC=C(C4=CC=CC=C4O)C=C3)=O
Target Point	AMPK
Passage	PI3K/Akt/mTOR;Epigenetics
Background	A-769662 is a potent, reversible AMPK activator.
Biological Activity	A-769662 是一种有效的，可逆的 AMPK 激活剂，EC50 值为 0.8 μM。[1-4]
Data Literature Source	[1]. Cool B，et al. Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. Cell Metab，2006，3(6)，403-416. [2]. Sanders MJ，et al. Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662，a member of the thienopyridone family. J Biol Chem，2007，282(45)，32539-32548. [3]. Moreno D，et al，A769662，a novel activator of AMP-activated protein kinase，inhibits non-proteolytic components of the 26S proteasome by an AMPK-independent mechanism. FEBS Lett，2008，583(17)，2650-2654. [4]. Yerra VG，et al. Adenosine Monophosphate-Activated Protein Kinase Abates Hyperglycaemia-Induced Neuronal Injury in Experimental Models of Diabetic Neuropathy: Effects on Mitochondrial Biogenesis，Autophagy and Neuroinflammation. Mol Neurobiol. 2017 Apr;54(3):2301-2312.
Unit	Bottle
Specification	2mg 5mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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