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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > NF-κB > 8-O-Acetyl Shanzhiside Methyl EsterCAS：57420-46-9
Molecular Formula：C19H28O12
Molecular Weight：448.42
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 57420-46-9 |
| Name | 8-O-Acetyl Shanzhiside Methyl Ester |
| Molecular Formula | C19H28O12 |
| Molecular Weight | 448.42 |
| Solubility | Soluble in Water/DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD15071141 |
| SMILES | O[C@H]([C@@H](O)[C@@H]1O)[C@](O[C@@H]1CO)([H])O[C@H]2[C@@]([C@@]3(C)OC(C)=O)([H])[C@@]([C@H](O)C3)([H])C(C(OC)=O)=CO2 |
| Target Point | NF-κB |
| Passage | NF-κB |
| Background | It inhibits NF-κB activity. |
| Biological Activity | 8-O-Acetyl shanzhiside methyl ester (ND01)是从中国西藏民间药用植物中分离出的环孢菌素葡萄糖苷。8-O-Acetyl shanzhiside methyl ester 可以抑制 NF-κB 活性。[1-4] |
| Data Literature Source | [1]. Zhang L，et al. 8-O-acetyl shanzhiside methylester attenuates cerebral ischaemia/reperfusion injury through an anti-inflammatory mechanism in diabetic rats. Basic Clin Pharmacol Toxicol. 2014 Dec;115(6):481-7. [2]. Kang ZC，et al. Cardioprotection with 8-O-acetyl shanzhiside methylester on experimental myocardial ischemia injury. Eur J Pharm Sci. 2012 Aug 30;47(1):124-30. [3]. Jiang WL，et al. Effect of 8-O-acetyl shanzhiside methylester increases angiogenesis and improves functional recovery after stroke. Basic Clin Pharmacol Toxicol. 2011 Jan;108(1):21-7. [4]. Fan PC，et al. A new anti-fibrinolytic hemostatic compound 8-O-acetyl shanzhiside methylester extracted from Lamiophlomis rotata. J Ethnopharmacol. 2016 Jul 1;187:232-8. |
| Unit | Bottle |
| Specification | 5mg 10mg 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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