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(+)-Tetrabenazine

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Cat.No：IT2720 Solarbio

CAS：1026016-83-0

Molecular Formula：C₁₉H₂₇NO₃

Molecular Weight：317.42

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	1026016-83-0
Name	(+)-Tetrabenazine
Molecular Formula	C₁₉H₂₇NO₃
Molecular Weight	317.42
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD08461052
SMILES	O=C([C@H](CC(C)C)C1)C[C@@]2([H])N1CCC3=C2C=C(OC)C(OC)=C3
InChIKey	MKJIEFSOBYUXJB-GDBMZVCRSA-N
InChI	InChI=1S/C19H27NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16H,5-7,10-11H2,1-4H3/t14-,16-/m1/s1
PubChem CID	667453
Target Point	VMAT-2
Passage	Membrane Transporter&Ion Channel
Background	(+)-Tetrabenazine is a reversible VMAT-2 inhibitor.
Biological Activity	(+)-Tetrabenazine ((+)-TBZ; (3R，11bR)-TBZ; (3R，11bR)-Tetrabenazine) is a reversible inhibitor of vesicular monoamine transporter 2 (VMAT-2)， inhibits transport by VMAT2 with 10-fold greater potency than transport by VMAT1.[1-2]
Data Literature Source	[1]. Podurgiel SJ et al. The MAO-B inhibitor deprenyl reduces the oral tremor and the dopamine depletion induced by the VMAT-2 inhibitor tetrabenazine. Behav Brain Res. 2016 Feb 1;298(Pt B):188-91. [2]. Peter D et al. Chimeric vesicular monoamine transporters identify structural domains that influence substrate affinity and sensitivity to tetrabenazine. J Biol Chem. 1996 Feb 9;271(6):2979-86.
Unit	Bottle
Specification	5mg 10mg 25mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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