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Brexpiprazole

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Cat.No：IB2630 Solarbio

CAS：913611-97-9

Molecular Formula：C₂₅H₂₇N₃O₂S

Molecular Weight：433.57

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	913611-97-9
Name	Brexpiprazole
Molecular Formula	C₂₅H₂₇N₃O₂S
Molecular Weight	433.57
Solubility	Soluble in DMSO ≥2mg/mL(Need ultrasonic)
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 811-628-7
MDL	MFCD27987920
SMILES	O=C1NC2=C(C=CC(OCCCCN3CCN(C4=C(C=CS5)C5=CC=C4)CC3)=C2)C=C1
Target Point	5-HT Receptor,Dopamine Receptor
Passage	Neuronal Signaling;GPCR & G Protein
Background	It is a novel partial agonist of dopamine receptor D2 and serotonin 1A receptor.
Biological Activity	Brexpiprazole (OPC-34712)是一种新型的多巴胺受体D2和5-羟色胺1A受体的部分激动剂，同时也是5-羟色胺2A受体和去甲肾上腺素alpha1B、alpha2C受体的拮抗剂。其对D2L, 5-HT1A, 5-HT2A, α1B受体和 α2C受体的Ki值分别为 0.3, 0.12, 0.47, 0.17 和 0.59 nM。[1]
IC50	5-HT1A(Cell-free assay):0.12nM(Ki);Dopamine D2L(Cell-free assay):0.3nM(Ki);5-HT2A receptors(Cell-free assay):0.47nM(Ki)[1]
Data Literature Source	[1] Ishima T，et al. Eur Neuropsychopharmacol. 2015，25(4):505-511. [2] Yoshimi N，et al. Pharmacol Biochem Behav. 2014，124:245-2
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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