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ADX-47273

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Cat.No：IA4750 Solarbio

CAS：851881-60-2

Molecular Formula：C₂₀H₁₇F₂N₃O₂

Molecular Weight：369.36

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	851881-60-2
Name	ADX-47273
Molecular Formula	C₂₀H₁₇F₂N₃O₂
Molecular Weight	369.36
Solubility	Soluble in DMSO ≥5mg/mL(Need ultrasonic)
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD17167026
SMILES	O=C(C1=CC=C(F)C=C1)N2C[C@@H](C3=NC(C4=CC=C(F)C=C4)=NO3)CCC2
Target Point	mGluR
Passage	GPCR & G Protein
Background	ADX-47273 is a positive allosteric modulator of mGluR5.
Biological Activity	ADX-47273 is a potent， selective and brain-penetrant mGluR5 positive allosteric modulator (PAM)， with an EC50 of 0.17 μM for potentiation of glutamate (50 nM) response. ADX-47273 has antipsychotic and procognitive activities[1-2].
IC50	mGluR5: 0.17μM(EC50)[1]
Data Literature Source	[1]. Liu F，et al. ADX47273 [S-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1，2，4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive. [2]. Schlumberger C，et，al. Effects of a positive allosteric modulator of mGluR5 ADX47273 on conditioned avoidance response and PCP-induced hyperlocomotion in the rat as models for schizophrenia. Pharmacol Biochem Behav. 2010 Mar;95(1):23-30. [3]. Xu J，et al. Potentiating mGluR5 function with a positive allosteric modulator enhances adaptive learning. Learn Mem. 2013 Jul 18;20(8):438-45.
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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