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My CartCAS：1051375-16-6
Molecular Formula：C20H19F2N3O5
Molecular Weight：419.38
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1051375-16-6 |
| Name | Dolutegravir |
| Molecular Formula | C20H19F2N3O5 |
| Molecular Weight | 419.38 |
| Solubility | Soluble in DMSO ≥5mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD20488027 |
| SMILES | O=C(C1=CN(C2=C(O)C1=O)C[C@]3([H])OCC[C@@H](C)N3C2=O)NCC4=CC=C(F)C=C4F |
| Target Point | HIV Integrase |
| Passage | Anti-infection |
| Background | It is a second-generation HIV integrase strand transfer inhibitor (INSTI). |
| Biological Activity | Dolutegravir是第二代HIV整合酶链转移抑制剂 (INSTI)，IC50 为 2.7 nM。[1-2] |
| Data Literature Source | [1]. Kobayashi M，et al. In Vitro antiretroviral properties of S/GSK1349572，a next-generation HIV integrase inhibitor. Antimicrob Agents Chemother. 2011 Feb;55(2):813-21. [2]. Moss L，et al. The comparative disposition and metabolism of dolutegravir，a potent HIV-1 integrase inhibitor，in mice，rats，and monkeys. Xenobiotica. 2015 Jan;45(1):60-70. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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