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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > PioglitazoneCAS：111025-46-8
Molecular Formula：C19H20N2O3S
Molecular Weight：356.44
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 111025-46-8 |
| Name | Pioglitazone |
| Molecular Formula | C19H20N2O3S |
| Molecular Weight | 356.44 |
| Solubility | Soluble in DMSO ≥1mg/mL;Soluble in Water ＜ 0.1mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 601-029-7 |
| MDL | MFCD00865504 |
| SMILES | O=C(N1)SC(CC2=CC=C(OCCC3=NC=C(CC)C=C3)C=C2)C1=O |
| InChIKey | HYAFETHFCAUJAY-UHFFFAOYSA-N |
| InChI | InChI=1S/C19H20N2O3S/c1-2-13-3-6-15(20-12-13)9-10-24-16-7-4-14(5-8-16)11-17-18(22)21-19(23)25-17/h3-8,12,17H,2,9-11H2,1H3,(H,21,22,23) |
| PubChem CID | 4829 |
| Target Point | PPAR |
| Passage | Cell Cycle;DNA Damage/DNA Repair;Metabolic Enzyme&Protease |
| Background | Pioglitazone is a potent and selective PPARγ agonist that binds with high affinity to the PPARγ ligand-binding domain. |
| Biological Activity | Pioglitazone 是一种有效的选择性 PPARγ 激动剂，高亲和力结合到 PPARγ 配体结合域。作用于人和鼠 PPARγ，EC50 分别为 0.93 和 0.99 μM。[1-4] |
| Data Literature Source | [1]. Kuwabara K，et al. A novel selective peroxisome proliferator-activated receptor alpha agonist，2-methyl-c-5-[4-[5-methyl-2-(4-methylphenyl)-4-oxazolyl]butyl]-1，3-dioxane-r-2-carboxylic acid (NS-220)，potently decreases plasma triglyceride and glucose leve [2]. Puddu A，et al. Pioglitazone attenuates the detrimental effects of advanced glycation end-products in the pancreatic beta cell line HIT-T15. Regul Pept. 2012 Aug 20;177(1-3):79-84. [3]. Kubota N，et al. Pioglitazone ameliorates insulin resistance and diabetes by both adiponectin-dependent and -independent pathways. J Biol Chem. 2006 Mar 31;281(13):8748-55. [4]. Elrashidy RA，et al. Pioglitazone attenuates cardiac fibrosis and hypertrophy in a rat model of diabetic nephropathy. J Cardiovasc Pharmacol Ther. 2012 Sep;17(3):324-33 |
| Unit | Bottle |
| Specification | 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Differential expression profiles of long noncoding RNAs and mRNAs in human bone marrow mesenchymal stem cells after exposure to a high dosage of dexamethasone
Click to check >>Author：Li T. Xu Y. Wang Y. Jiang Y
IF：5.0810
Publish_to：Stem Cell Res Ther
PMID：33407832
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