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PF-8380

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Cat.No：IP3650 Solarbio

CAS：1144035-53-9

Molecular Formula：C₂₂H₂₁Cl₂N₃O₅

Molecular Weight：478.33

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Off-white to brown Solid

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Product Information

CAS	1144035-53-9
Name	PF-8380
Molecular Formula	C₂₂H₂₁Cl₂N₃O₅
Molecular Weight	478.33
Solubility	Soluble in DMSO ≥5mg/mL
Purity	≥98%
Appearance	Off-white to brown Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD20527274
SMILES	O=C(N1CCN(CCC(C2=CC=C3NC(OC3=C2)=O)=O)CC1)OCC4=CC(Cl)=CC(Cl)=C4
Target Point	Phosphodiesterase (PDE)
Passage	Metabolic Enzyme&Protease
Background	PF-8380 is a novel, potent and specific inhibitor of autotaxin (ATX).
Biological Activity	PF-8380 is a potent autotaxin inhibitor with an IC50 of 2.8 nM in isolated enzyme assay and 101 nM in human whole blood.[1-3]
Data Literature Source	[1]. Gierse J， et al. A novel autotaxin inhibitor reduces lysophosphatidic acid levels in plasma and the site of inflammation. J Pharmacol Exp Ther. 2010 Jul;334(1):310-7. [2]. Bhave SR， et al. Autotaxin Inhibition with PF-8380 Enhances the Radiosensitivity of Human and Murine Glioblastoma Cell Lines. Front Oncol. 2013 Sep 17;3:236. [3]. Cao P， et al. Autocrine lysophosphatidic acid signaling activates β-catenin and promotes lung allograft fibrosis. J Clin Invest. 2017 Apr 3;127(4):1517-1530.
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.

2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.

3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.