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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > EvacetrapibCAS：1186486-62-3
Molecular Formula：C31H36F6N6O2
Molecular Weight：638.65
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 1186486-62-3 |
| Name | Evacetrapib |
| Molecular Formula | C31H36F6N6O2 |
| Molecular Weight | 638.65 |
| Solubility | Soluble in DMSO ≥1mg/mL;Soluble in Water ＜ 1mg/mL |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00941390 |
| SMILES | O=C([C@H]1CC[C@H](CN2C3=C(C)C=C(C)C=C3[C@@H](N(CC4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)C5=NN(C)N=N5)CCC2)CC1)O |
| Target Point | CETP |
| Passage | Metabolic Enzyme&Protease |
| Background | It is a potent and selective CETP inhibitor. |
| Biological Activity | Evacetrapib 是一种有效的选择性的 CETP 抑制剂，在人血浆中，抑制人重组 CETP 蛋白 (IC50 为 5.5 nM) 和 CETP 活性，IC50 为 36 nM。[1] |
| IC50 | 5.5nM(CETP)[1] |
| Data Literature Source | [1]. Cao G，et al. Evacetrapib is a novel，potent，and selective inhibitor of cholesteryl ester transfer protein that elevates HDL cholesterol without inducing aldosterone or increasing blood pressure. J Lipid Res. 2011 Dec;52(12):2169-76. |
| Unit | Bottle |
| Specification | 1mg 2mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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