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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > U-104CAS：178606-66-1
Molecular Formula：C13H12FN3O3S
Molecular Weight：309.32
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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| CAS | 178606-66-1 |
| Name | U-104 |
| Molecular Formula | C13H12FN3O3S |
| Molecular Weight | 309.32 |
| Solubility | Soluble in DMSO ≥5mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00159265 |
| SMILES | NS(C1=CC=C(NC(NC2=CC=C(F)C=C2)=O)C=C1)(=O)=O |
| Target Point | Carbonic Anhydrase |
| Passage | Metabolic Enzyme&Protease |
| Background | It is a highly effective inhibitor of carbonic anhydrase (Carbonic anhydrase) CA IX and CA XII. |
| Biological Activity | U-104 (SLC-0111) is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with Ki values of 45.1 nM and 4.5 nM, respectively. U-104 shows a significant delay in tumor growth in mice model[1-2]. |
| IC50 | Ki: 45.1nM(CA IX) and 4.5nM(CA XII)[1]EC50: 0.2μM(exosome)[3] |
| Data Literature Source | [1]. Lou Y，et al. Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors. Cancer Res. 2011 May 1;71(9):3364-76. [2]. Lock FE，et al. Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche. Oncogene. 2013 Oct 31;32(44):5210-9. [3]. Huarui Zhang，et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1322-1330. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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