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My CartCAS：134-03-2
Molecular Formula：C6H7NaO6
Molecular Weight：198.11
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Off-white to light yellow Solid
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| CAS | 134-03-2 |
| Name | Sodium Ascorbate |
| Molecular Formula | C6H7NaO6 |
| Molecular Weight | 198.11 |
| Solubility | Soluble in Water ≥10mg/mL |
| Purity | ≥98% |
| Appearance | Off-white to light yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 205-126-1 |
| MDL | MFCD00082340 |
| SMILES | C(C(C1C(=C(C(=O)O1)O)[O-])O)O.[Na+] |
| Target Point | Cav3.2 channels |
| Passage | Membrane Transporter&Ion Channel;Neuronal Signaling |
| Background | Sodium Ascorbate is an electron donor and endogenous antioxidant， as well as a collagen deposition promoter and elastogenesis inhibitor. Sodium Ascorbate can selectively inhibit Cav3.2 channels. |
| Biological Activity | L-Ascorbic acid sodium salt (Sodium L-ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid sodium salt inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid sodium salt is also a collagen deposition enhancer and an elastogenesis inhibitor[1-3]. |
| Data Literature Source | [1]. Hinek A，et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75(3):173-82. [2]. Aleksander Hinek，et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75(3):173-82. [3]. Michael T Nelson，et al. Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate. J Neurosci. 2007 Nov 14;27(46):12577-83. [4]. Yang X，et al. Mouse melanoma cell line B16F10-derived conditioned medium inhibits sodium L-ascorbate-induced B16F10 cell apoptosis. Nan Fang Yi Ke Da Xue Xue Bao. 2012 Feb;32(2):146-50. [5]. Morimura K，et al. Lack of urinary bladder carcinogenicity of sodium L-ascorbate in human c-Ha-ras proto-oncogene transgenic rats. Toxicol Pathol. 2005;33(7):764-7. [6]. Takagi H，et al. Limited tumor-initiating activity of phenylethyl isothiocyanate by promotion with sodium L-ascorbate in a rat two-stage urinary bladder carcinogenesis model. Cancer Lett. 2005 Mar 10;219(2):147-53. |
| Unit | Bottle |
| Specification | 100mg 10mM*1mL in Water 200mg 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
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