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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > RoflumilastCAS：162401-32-3
Molecular Formula：C17H14Cl2F2N2O3
Molecular Weight：403.21
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 162401-32-3 |
| Name | Roflumilast |
| Molecular Formula | C17H14Cl2F2N2O3 |
| Molecular Weight | 403.21 |
| Solubility | Soluble in DMSO ≥5mg/mL;Soluble in Water ＜ 0.1mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 223-583-8 |
| MDL | MFCD00938270 |
| SMILES | O=C(NC1=C(Cl)C=NC=C1Cl)C2=CC=C(OC(F)F)C(OCC3CC3)=C2 |
| Target Point | Phosphodiesterase (PDE) |
| Passage | Metabolic Enzyme&Protease |
| Background | Roflumilast is a selective PDE4 inhibitor. |
| Biological Activity | Roflumilast 是一种选择性的 PDE4 抑制剂，作用于 PDE4A1，PDEA4，PDEB1 和 PDEB2，IC50 分别为 0.7，0.9，0.7 和 0.2 nM。[1-5] |
| IC50 | 0.7nM(PDE4A1)，0.9nM(PDE4A4)，0.7nM(PDE4B1)，0.2nM(PDE4B2)[1] |
| Data Literature Source | [1]. Hatzelmann A，et al. The preclinical pharmacology of roflumilast--a selective，oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease. Pulm Pharmacol Ther. 2010 Aug;23(4):235-56. [2]. Rabe KF. Update on roflumilast，a phosphodiesterase 4 inhibitor for the treatment of chronic obstructive pulmonary disease. Br J Pharmacol. 2011 May;163(1):53-67. [3]. Hatzelmann A，et al. Anti-inflammatory and immunomodulatory potential of the novel PDE4 inhibitor roflumilast in vitro. J Pharmacol Exp Ther. 2001 Apr;297(1):267-79. [4]. Richmond BW，et al. Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency. Nat Commun. 2016 Apr 5;7:11240. [5]. Ding H，et al. Treatment of obesity-associated overactive bladder by the phosphodiesterase type-4 inhibitor roflumilast. Int Urol Nephrol. 2017 Jul 29 |
| Unit | Bottle |
| Specification | 5mg 10mg 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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