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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > BAY-1436032CAS：1803274-65-8
Molecular Formula：C26H30F3N3O3
Molecular Weight：489.53
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1803274-65-8 |
| Name | BAY-1436032 |
| Molecular Formula | C26H30F3N3O3 |
| Molecular Weight | 489.53 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | O=C(O)CCC1=CC=C2C(N=C(NC3=CC=C(OC(F)(F)F)C=C3)N2[C@H]4CC(C)(C)C[C@@H](C)C4)=C1 |
| Target Point | Isocitrate Dehydrogenase (IDH) |
| Passage | Metabolic Enzyme&Protease |
| Background | It is a highly selective and potent mIDH1 inhibitor. |
| Biological Activity | BAY-1436032是具有高度选择性的、有效的、具有口服生物利用度的mIDH1抑制剂。BAY-1436032对多种IDH1-R132X突变体的酶活性具有两位数纳摩尔级别的效力。在患者来源或是表达不同IDH1突变的工程细胞系中，BAY-1436032能有效地抑制2-HG的释放。[1] |
| Data Literature Source | [1] Pusch S，et al. Acta Neuropathol. 2017，133(4):629-644. |
| Unit | Bottle |
| Specification | 2mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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