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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > Abiraterone AcetateCAS：154229-18-2
Molecular Formula：C26H33NO2
Molecular Weight：391.55
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 154229-18-2 |
| Name | Abiraterone Acetate |
| Molecular Formula | C26H33NO2 |
| Molecular Weight | 391.55 |
| Solubility | Soluble in DMSO ≥1mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 620-314-7 |
| MDL | MFCD00934213 |
| SMILES | O=C(O[C@@H]1CC2=CC[C@]3([H])[C@]([H])(CC[C@](C)(C(C4=CN=CC=C4)=CC5)[C@]35[H])[C@@]2(C)CC1)C |
| Target Point | Cytochrome P450 |
| Passage | Metabolic Enzyme&Protease |
| Background | It is a steroidal cytochrome CYP17 inhibitor. |
| Biological Activity | Abiraterone acetate是口服，有效，选择性和不可逆的 CYP17 抑制剂。[1-4] |
| Data Literature Source | [1]. Stein MN，et al. Androgen synthesis inhibitors in the treatment of castration-resistant prostate cancer. Asian J Androl. 2014 May-Jun;16(3):387-400. [2]. Richards J，et al. Interactions of abiraterone，eplerenone，and prednisolone with wild-type and mutant androgen receptor: a rationale for increasing abiraterone exposure or combining with MDV3100. Cancer Res. 2012 May 1;72(9):2176-82. [3]. Li R，et al. Abiraterone inhibits 3β-hydroxysteroid dehydrogenase: a rationale for increasing drug exposure in castration-resistant prostate cancer. Clin Cancer Res. 2012 Jul 1;18(13):3571-9. [4]. Lee GT，et al. Intracrine androgen biosynthesis in renal cell carcinoma. Br J Cancer. 2017 Mar 28;116(7):937-943. |
| Unit | Bottle |
| Specification | 10mg 25mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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