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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > DNA Damage & DNA Repai > LomeguatribCAS：192441-08-0
Molecular Formula：C10H8BrN5OS
Molecular Weight：326.17
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 192441-08-0 |
| Name | Lomeguatrib |
| Molecular Formula | C10H8BrN5OS |
| Molecular Weight | 326.17 |
| Solubility | Soluble in DMSO ≥5mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD23703756 |
| SMILES | NC1=NC(OCC2=CC(Br)=CS2)=C3N=CNC3=N1 |
| Target Point | DNA-alkyltransferase(MGMT) |
| Passage | DNA Damage/DNA Repair |
| Background | Lomeguatrib is a potent MGMT inhibitor. |
| Biological Activity | Lomeguatrib 是一种有效的 MGMT 抑制剂，在非细胞体系和 MCF-7 细胞体系中，IC50 值分别为 9 nM 和 ～6 nM。[1-2] |
| Data Literature Source | [1]. Reinhard J，et al. Monosaccharide-linked inhibitors of O(6)-methylguanine-DNA methyltransferase (MGMT): synthesis，molecular modeling，and structure-activity relationships. J Med Chem. 2001 Nov 22;44(24):4050-61. [2]. Clemons M，et al. O6-(4-bromothenyl)guanine reverses temozolomide resistance in human breast tumour MCF-7 cells and xenografts. Br J Cancer. 2005 Nov 14;93(10):1152-6. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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