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Lonafarnib

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Cat.No：IL1830 Solarbio

CAS：193275-84-2

Molecular Formula：C₂₇H₃₁Br₂ClN₄O₂

Molecular Weight：638.82

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	193275-84-2
Name	Lonafarnib
Molecular Formula	C₂₇H₃₁Br₂ClN₄O₂
Molecular Weight	638.82
Solubility	Soluble in DMSO ≥10mg/mL
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD06795138
SMILES	O=C(N1CCC(CC(N2CCC([C@@H]3C4=C(Br)C=C(Cl)C=C4CCC5=CC(Br)=CN=C53)CC2)=O)CC1)N
Target Point	FPTase，H-ras，K-ras , N-ras
Passage	Metabolic Enzyme&Protease
Background	Lonafarnib is a potent FPTase inhibitor that acts on H-ras, K-ras-4B and N-ras.
Biological Activity	Lonafarnib 是一种口服有效的法尼基蛋白转移酶 (FPTase) 抑制剂，作用于 H-ras，K-ras 和 N-ras，IC50 分别为 1.9 nM，5.2 nM 和 2.8 nM。[1-2]
IC50	1.9nM(H-ras)，5.2nM(K-ras)，2.8nM(N-ras)[1]
Data Literature Source	[1]. Liu M，et al. Antitumor activity of SCH 66336，an orally bioavailable tricyclic inhibitor of farnesyl protein transferase，in human tumor xenograft models and wap-ras transgenic mice. Cancer Res. 1998 Nov 1;58(21):4947-56. [2]. Chaponis D，et al. Lonafarnib (SCH66336) improves the activity of temozolomide and radiation for orthotopic malignant gliomas. J Neurooncol. 2011 Aug;104(1):179-89.
Unit	Bottle
Specification	1mg 5mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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