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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > OxaprozinCAS：21256-18-8
Molecular Formula：C18H15NO3
Molecular Weight：293.32
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 21256-18-8 |
| Name | Oxaprozin |
| Molecular Formula | C18H15NO3 |
| Molecular Weight | 293.32 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 244-296-1 |
| MDL | MFCD00215977 |
| SMILES | O=C(O)CCC1=NC(C2=CC=CC=C2)=C(C3=CC=CC=C3)O1 |
| InChIKey | OFPXSFXSNFPTHF-UHFFFAOYSA-N |
| InChI | InChI=1S/C18H15NO3/c20-16(21)12-11-15-19-17(13-7-3-1-4-8-13)18(22-15)14-9-5-2-6-10-14/h1-10H,11-12H2,(H,20,21) |
| PubChem CID | 4614 |
| Target Point | COX |
| Passage | Immunology & Inflammation |
| Background | It is an inhibitor of COX-1 and COX-2, and also inhibits the activation of NF-κB. |
| Biological Activity | Oxaprozin 是 COX-1 和 COX-2 的抑制剂，对人类血小板 COX-1 和 IL-1 刺激的人类滑膜细胞 COX-2 的 IC50 值分别为 2.2 和 36 μM。Oxaprozin 还能抑制 NF-κB 的活化。[1-2] |
| Data Literature Source | [1]. Ottonello L，et al. Delayed apoptosis of human monocytes exposed to immune complexes is reversed byoxaprozin: role of the Akt/IkappaB kinase/nuclear factor kappaB pathway. Br J Pharmacol. 2009 May;157(2):294-306. [2]. Montecucco F，et al. Oxaprozin-induced apoptosis on CD40 ligand-treated human primary monocytes is associated with the modulation of defined intracellular pathways. J Biomed Biotechnol. 2009;2009:478785. |
| Unit | Bottle |
| Specification | 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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