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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > DarapladibCAS：356057-34-6
Molecular Formula：C36H38F4N4O2S
Molecular Weight：666.77
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 356057-34-6 |
| Name | Darapladib |
| Molecular Formula | C36H38F4N4O2S |
| Molecular Weight | 666.77 |
| Solubility | Soluble in DMSO ≥10mg/mL;Soluble in Water ＜ 1mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD18251452 |
| SMILES | FC1=CC=C(CSC(N(CC(N(CCN(CC)CC)CC2=CC=C(C3=CC=C(C(F)(F)F)C=C3)C=C2)=O)C4=C5CCC4)=NC5=O)C=C1 |
| Target Point | Phospholipase（(Lp-PLA2)） |
| Passage | Metabolic Enzyme&Protease |
| Background | Darapladib is an irreversible lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor. |
| Biological Activity | Darapladib 是一种有效的脂蛋白相关磷脂酶A2 (Lp-PLA2) 抑制剂，IC50 为 0.25 nM。[1-2] |
| IC50 | 0.25nM(Lp-PLA2)[1] |
| Data Literature Source | [1]. Blackie JA，et al. The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A2. Bioorg Med Chem Lett. 2003 Mar 24;13(6):1067-70. [2]. Hu MM，et al. The inhibition of lipoprotein-associated phospholipase A2 exerts beneficial effects against atherosclerosis inLDLR-deficient mice. Acta Pharmacol Sin. 2011 Oct;32(10):1253-1258 |
| Unit | Bottle |
| Specification | 2mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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