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Rivaroxaban

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Cat.No：IR1060 Solarbio

CAS：366789-02-8

Molecular Formula：C₁₉H₁₈ClN₃O₅S

Molecular Weight：435.88

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	366789-02-8
Name	Rivaroxaban
Molecular Formula	C₁₉H₁₈ClN₃O₅S
Molecular Weight	435.88
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 685-132-2
MDL	MFCD11974010
SMILES	O=C(N(C1=CC=C(N2C(COCC2)=O)C=C1)C3)O[C@H]3CNC(C4=CC=C(S4)Cl)=O
Target Point	Factor Xa
Passage	Metabolic Enzyme&Protease
Background	Rivaroxaban is a direct inhibitor of Factor Xa.
Biological Activity	Rivaroxaban 是一种高效的选择性Factor Xa (FXa) 抑制剂，具有强效抗FXa活性 (IC50 为 0.7 nM，Ki 为 0.4 nM)。[1-2]
IC50	0.7nM(FXa)[1] Ki: 0.4nM(FXa)[1]
Data Literature Source	[1]. Roehrig S，et al. Discovery of the novel antithrombotic agent 5-chloro-N-({(5S)-2-oxo-3- [4-(3-oxomorpholin-4-yl)phenyl]-1，3-oxazolidin-5-yl}methyl)thiophene- 2-carboxamide (BAY 59-7939): an oral，direct factor Xa inhibitor. J Med Chem. 2005 Sep 22;48(19) [2]. Perzborn E，et al. In vitro and in vivo studies of the novel antithrombotic agent BAY 59-7939--an oral，direct Factor Xa inhibitor. J Thromb Haemost. 2005 Mar;3(3):514-21.
Unit	Bottle
Specification	2mg 5mg 10mg 20mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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