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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > Fenofibric AcidCAS：42017-89-0
Molecular Formula：C17H15ClO4
Molecular Weight：318.75
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 42017-89-0 |
| Name | Fenofibric Acid |
| Molecular Formula | C17H15ClO4 |
| Molecular Weight | 318.75 |
| Solubility | Soluble in DMSO ≥5mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 255-626-9 |
| MDL | MFCD00792461 |
| SMILES | CC(C)(OC1=CC=C(C(C2=CC=C(Cl)C=C2)=O)C=C1)C(O)=O |
| InChIKey | MQOBSOSZFYZQOK-UHFFFAOYSA-N |
| InChI | InChI=1S/C17H15ClO4/c1-17(2,16(20)21)22-14-9-5-12(6-10-14)15(19)11-3-7-13(18)8-4-11/h3-10H,1-2H3,(H,20,21) |
| PubChem CID | 64929 |
| Target Point | PPAR，COX2 |
| Passage | Cell Cycle;DNA Damage/DNA Repair;Metabolic Enzyme&Protease;Immunology & Inflammation; |
| Background | Fenofibric Acid is a PPAR agonist; also inhibits COX-2 activity. |
| Biological Activity | Fenofibric acid 是 fenofibrate 的活性代谢物，为 PPAR 激动剂，对 PPARα，PPARγ 和 PPARδ 的 EC50 值分别为 22.4 μM，1.47 μM 和 1.06 μM；Fenofibric acid 同时可抑制 COX-2 的活性，IC50 值为 48 nM。[1-4] |
| Data Literature Source | [1]. Dietz M，et al. Comparative molecular profiling of the PPARα/γ activator aleglitazar: PPAR selectivity，activity and interaction with cofactors. ChemMedChem. 2012 Jun;7(6):1101-11. [2]. Prasad GS，et al. Anti-inflammatory activity of anti-hyperlipidemic drug，fenofibrate，and its phase-I metabolite fenofibric acid: in silico，in vitro，and in vivo studies. Inflammopharmacology. 2017 Dec 13. [3]. Neumeier M，et al. Aldehyde oxidase 1 is highly abundant in hepatic steatosis and is downregulated by adiponectin and fenofibric acid in hepatocytes in vitro. Biochem Biophys Res Commun. 2006 Nov 24;350(3):731-5. Epub 2006 Sep 27. [4]. Miranda S，et al. Beneficial effects of fenofibrate in retinal pigment epithelium by the modulation of stress and survival signaling under diabetic conditions. J Cell Physiol. 2012 Jun;227(6):2352-62 |
| Unit | Bottle |
| Specification | 250mg 500mg 1g |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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