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Pirinixic Acid

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Cat.No：IP4080 Solarbio

CAS：50892-23-4

Molecular Formula：C₁₄H₁₄ClN₃O₂S

Molecular Weight：323.8

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	50892-23-4
Name	Pirinixic Acid
Molecular Formula	C₁₄H₁₄ClN₃O₂S
Molecular Weight	323.8
Solubility	Soluble in DMSO ≥1mg/mL(Need ultrasonic)
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD00191335
SMILES	O=C(O)CSC1=NC(NC2=CC=CC(C)=C2C)=CC(Cl)=N1
InChIKey	SZRPDCCEHVWOJX-UHFFFAOYSA-N
InChI	InChI=1S/C14H14ClN3O2S/c1-8-4-3-5-10(9(8)2)16-12-6-11(15)17-14(18-12)21-7-13(19)20/h3-6H,7H2,1-2H3,(H,19,20)(H,16,17,18)
PubChem CID	5694
Target Point	PPARα
Passage	Cell Cycle;DNA Damage/DNA Repair;Metabolic Enzyme&Protease
Background	Pirinixic Acid is a potent PPARα activator.
Biological Activity	Pirinixic acid (Wy-14643) 是一种有效的 PPARα 激动剂，对鼠的 PPARα 和 PPARγ 的 EC50 值分别为 0.63 μM, 32 μM，对人的 PPARα，PPARγ 和 PPARδ 的 EC50 值分别为 5.0 μM，60 μM，35 μM。[1-3]
Data Literature Source	[1]. Willson TM，et al. The PPARs: from orphan receptors to drug discovery. J Med Chem. 2000 Feb 24;43(4):527-50. [2]. Huang D，et al. PPAR-α Agonist WY-14643 Inhibits LPS-Induced Inflammation in Synovial Fibroblasts via NF-kB Pathway. J Mol Neurosci. 2016 Aug;59(4):544-53. [3]. Pantazi E，et al. PPARα Agonist WY-14643 Induces SIRT1 Activity in Rat Fatty Liver Ischemia-Reperfusion Injury. Biomed Res Int. 2015;2015:894679.
Unit	Bottle
Specification	10mg 50mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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