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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > GPCR & G Protein > A2AR Antagonist 1CAS：443103-97-7
Molecular Formula：C16H12FN5O
Molecular Weight：309.3
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 443103-97-7 |
| Name | A2AR Antagonist 1 |
| Molecular Formula | C16H12FN5O |
| Molecular Weight | 309.3 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | C1=CC=C(C(=C1)CN2C3=NC(=NC(=C3C=N2)C4=CC=CO4)N)F |
| Target Point | Adenosine A2A receptor |
| Passage | GPCR & G Protein |
| Background | A2AR antagonist 1 is a potent A2AR (Adenosine A2A Receptor) antagonist. |
| Biological Activity | A2A receptor antagonist 1 (CPI-444 analog) is an antagonist of both adenosine A2A receptor and A1 receptor with Ki values of 4 and 264 nM， respectively[1]. |
| IC50 | Ki: 4nM(adenosine A2A receptor)，264nM(A1 receptor)[1] |
| Data Literature Source | [1]. Gillespie RJ，et al. Antagonists of the human adenosine A2A receptor. Part 3: Design and synthesis of pyrazolo[3，4-d]pyrimidines，pyrrolo[2，3-d]pyrimidines and 6-arylpurines. Bioorg Med Chem Lett. 2008 May 1;18(9):2924-9. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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