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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > 5-IodotubercidinCAS：24386-93-4
Molecular Formula：C11H13IN4O4
Molecular Weight：392.15
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 24386-93-4 |
| Name | 5-Iodotubercidin |
| Molecular Formula | C11H13IN4O4 |
| Molecular Weight | 392.15 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-001-2 |
| MDL | MFCD00055131 |
| SMILES | NC1=C2C(N([C@H]3[C@H](O)[C@H](O)[C@@H](CO)O3)C=C2I)=NC=N1 |
| Target Point | Adenosine Kinase |
| Passage | Metabolic Enzyme&Protease |
| Background | It is a potent adenosine kinase inhibitor. |
| Biological Activity | 5-Iodotubercidin 是一种有效的腺苷激酶抑制剂，IC50 值为 26 nM。[1-5] |
| Data Literature Source | [1]. Massillon D，et al. Identification of the glycogenic compound 5-iodotubercidin as a general protein kinase inhibitor. Biochem J. 1994 Apr 1;299 (Pt 1):123-8. [2]. Ugarkar BG，et al. Adenosine kinase inhibitors. 1. Synthesis，enzyme inhibition，and antiseizure activity of 5-iodotubercidin analogues. J Med Chem. 2000 Jul 27;43(15):2883-93. [3]. García-Villafranca J，et al. Effects of 5-iodotubercidin on hepatic fatty acid metabolism mediated by the inhibition of acetyl-CoA carboxylase. Biochem Pharmacol. 2002 Jun 1;63(11):1997-2000. [4]. De Antoni A，et al. A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B. J Cell Biol. 2012 Oct 15;199(2):269-84. [5]. Acharya MM，et al. Adenosine Kinase Inhibition Protects against Cranial Radiation-Induced Cognitive Dysfunction. Front Mol Neurosci. 2016 Jun 3;9:42 |
| Unit | Bottle |
| Specification | 2mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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