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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > DNA Damage & DNA Repai > Tubastatin A HydrochlorideCAS：1310693-92-5
Molecular Formula：C20H21N3O2·HCl
Molecular Weight：371.86
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to brown Solid
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| CAS | 1310693-92-5 |
| Name | Tubastatin A Hydrochloride |
| Molecular Formula | C20H21N3O2·HCl |
| Molecular Weight | 371.86 |
| Solubility | Soluble in DMSO ≥1mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to brown Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD20488052 |
| SMILES | O=C(C1=CC=C(C=C1)CN2C3=C(C4=C2C=CC=C4)CN(C)CC3)NO.[H]Cl |
| Target Point | HDAC |
| Passage | DNA Damage/DNA Repair;Epigenetics;NF-κB |
| Background | Tubastatin A Hydrochloride is a potent and selective HDAC6 inhibitor. |
| Biological Activity | Tubastatin A Hydrochloride 是一种有效的，选择性的 HDAC6 抑制剂，IC50 值为 15 nM，对其选择性是 HDAC8 外的其他亚型的 1000 多倍。[1-5] |
| Data Literature Source | [1]. Kyle V. Butler et al. Rational Design and Simple Chemistry Yield a Superior，Neuroprotective HDAC6 Inhibitor，Tubastatin A J. Am. Chem. Soc.，2010，132 (31)，pp 10842-10846 [2]. de Zoeten EF，et al. Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3(+) T-regulatory cells. Mol Cell Biol. 2011 May;31(10):2066-78. [3]. Di Fulvio S，et al. Dysferlin interacts with histone deacetylase 6 and increases alpha-tubulin acetylation. PLoS One. 2011;6(12):e28563 [4]. Ketene AN，et al. Actin filaments play a primary role for structural integrity and viscoelastic response in cells. Integr Biol (Camb). 2012 May;4(5):540-9. [5]. Brijmohan AS，et al. HDAC6 Inhibition Promotes Transcription Factor EB Activation and Is Protective in Experimental Kidney Disease. Front Pharmacol. 2018 Feb 1;9:34. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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